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Registro completo
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Biblioteca (s) : |
INIA Tacuarembó. |
Fecha : |
21/02/2014 |
Actualizado : |
20/12/2021 |
Tipo de producción científica : |
Documentos |
Autor : |
SCMAU (SOCIEDAD DE CRIADORES MERINO AUTRALIANO DEL URUGUAY); MGAP (MINISTERIO GANADERÍA AGRICULTURA Y PESCA); INIA (INSTITUTO NACIONAL DE INVESTIGACIÓN AGROPECUARIA); SUL (SECRETARIADO URUGUAYO DE LA LANA). |
Título : |
Proyecto Merino Fino del Uruguay - Fases I y II: Tercera evaluación genética poblacional de animales de la raza merino australiano en el Uruguay, sumario de padres 1995 - 2004 |
Fecha de publicación : |
2005 |
Fuente / Imprenta : |
Montevideo (Uruguay): INIA, 2005. |
Páginas : |
37 p |
Idioma : |
Español |
Contenido : |
El presente, es el tercer Sumario de Padres publicado de carneros participantes de la Tercera Evaluación Genética Poblacional de la Raza Merino Australiano.
Los resultados de este informe se obtuvieron a partir de la información proveniente de las CPP, del NFG y de las Cabañas participantes del Proyecto Merino Fino Fase I (1995-2004), donde se incluyeron solamente las cabañas “conectadas” entre si, excluyéndose las “desconectadas”. A estas últimas se les realizo una evaluación genética interna, por lo tanto, la información de las mismas no podrá ser comparada con el resto de los animales provenientes de las cabañas que sí disponen de conexión.
La Tercera Evaluación Genética Poblacional pone a disposición la información de 227 padres, donde treinta y siete de estos disponen de evaluación genética como borregos, certificando su valor genético a través de las DEPs de las principales características de interés económico para la producción de lana fina y superfina, generados a través de la evaluación genealógica y productiva de más de 17.200 animales. |
Thesagro : |
MERINO; OVINOS; RAZAS (ANIMALES); URUGUAY. |
Asunto categoría : |
-- |
URL : |
http://www.inia.uy/Publicaciones/Documentos%20compartidos/EvalGenPobl2005.pdf
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Marc : |
LEADER 01876nam a2200205 a 4500 001 1017743 005 2021-12-20 008 2005 bl uuuu u00u1 u #d 100 1 $aSCMAU (SOCIEDAD DE CRIADORES MERINO AUTRALIANO DEL URUGUAY) 245 $aProyecto Merino Fino del Uruguay - Fases I y II$bTercera evaluación genética poblacional de animales de la raza merino australiano en el Uruguay, sumario de padres 1995 - 2004 260 $aMontevideo (Uruguay): INIA$c2005 300 $a37 p 520 $aEl presente, es el tercer Sumario de Padres publicado de carneros participantes de la Tercera Evaluación Genética Poblacional de la Raza Merino Australiano. Los resultados de este informe se obtuvieron a partir de la información proveniente de las CPP, del NFG y de las Cabañas participantes del Proyecto Merino Fino Fase I (1995-2004), donde se incluyeron solamente las cabañas “conectadas” entre si, excluyéndose las “desconectadas”. A estas últimas se les realizo una evaluación genética interna, por lo tanto, la información de las mismas no podrá ser comparada con el resto de los animales provenientes de las cabañas que sí disponen de conexión. La Tercera Evaluación Genética Poblacional pone a disposición la información de 227 padres, donde treinta y siete de estos disponen de evaluación genética como borregos, certificando su valor genético a través de las DEPs de las principales características de interés económico para la producción de lana fina y superfina, generados a través de la evaluación genealógica y productiva de más de 17.200 animales. 650 $aMERINO 650 $aOVINOS 650 $aRAZAS (ANIMALES) 650 $aURUGUAY 700 1 $aMGAP (MINISTERIO GANADERÍA AGRICULTURA Y PESCA) 700 1 $aINIA (INSTITUTO NACIONAL DE INVESTIGACIÓN AGROPECUARIA) 700 1 $aSUL (SECRETARIADO URUGUAYO DE LA LANA).
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| Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
Fecha actual : |
07/06/2022 |
Actualizado : |
30/11/2022 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Circulación / Nivel : |
Internacional - -- |
Autor : |
MACHADO, M.; CASTRO, M.B.; WILSON, T. M.; GONÇALVES , A. A. B.; PORTIANSKY, E.; RIET-CORREA, F.; BARROS, S. S. |
Afiliación : |
MIZAEL MACHADO DA COSTA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MÁRCIO B. CASTRO, University of Brasilia, Brasília, Brazil; TAIS M. WILSON, University of Brasilia, Brasília, Brazil; ALEXANDRA A. B. GONÇALVES, University of Brasilia, Brasília, Brazil; ENRIQUE L. PORTIANSKY, National University of La Plata, La Plata, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina; FRANKLIN RIET-CORREA AMARAL, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; Federal University of Bahia, Salvador, Brazil; SEVERO S. BARROS, Federal University of Santa Maria, Rio Grande do Sul, Brazil. |
Título : |
Poisoning by Nierembergia veitchii: Effects on vascular smooth muscle cells in the pathogenesis of enzootic calcinosis. |
Fecha de publicación : |
2022 |
Fuente / Imprenta : |
Veterinary Pathology, 2022, Volume 59, Issue 5, pages 814-823. doi: https://doi.org/10.1177/03009858221098430 |
ISSN : |
0300-9858 |
DOI : |
10.1177/03009858221098430 |
Idioma : |
Inglés |
Notas : |
Article history: Article first published online May 19, 2022; Published online September 2022. -- Corresponding Author: Franklin Riet-Correa, Postgraduate Program in Animal Science in the Tropics, School of Veterinary Medicine and Animal Science, Federal University of Bahia, Salvador, Bahia 40170-110, Brazil. Email: franklinrietcorrea@gmail.com -- This work was funded by National Institute of Agricultural Research (INIA) of Uruguay (Project CL 44), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil, (Finance Code 001) and National University of La Plata (Project V270). A postgraduate scholarship was provided to Mizael Machado by INIA, Uruguay. |
Contenido : |
ABSTRACT - Vascular mineralization is a hallmark of enzootic calcinosis. Histopathological, ultrastructural, and immunohistochemical investigations were performed on the external carotid arteries of seven sheep naturally poisoned by Nierembergia veitchii. Histologically, moderate to marked hyperplasia of the tunica intima was observed without mineralization. The tunica media exhibited mild to severe mineralization and osteochondroid metaplasia. Sheep with enzootic calcinosis showed arterial overexpression of osteopontin and tissue-nonspecific alkaline phosphatase and immunolabeling for osteonectin and osteocalcin in both intima and media layers of the tested arteries. The main ultrastructural finding in the tunica media was a marked phenotypic change of vascular smooth muscle cells from a contractile phenotype (VSMC-C) into a synthetic phenotype (VSMC-S). In the tunica media, VSMC-S produced matrix and extracellular vesicles, forming mineralizable granules associated with arterial mineralization. VSMC-S were also present in the tunica intima, but matrix and extracellular vesicles and mineralization were not observed. The absence of matrix and extracellular vesicles in the intimal hyperplasia, even in the presence of noncollagenous bone proteins, tissue-nonspecific alkaline phosphatase, and vitamin D receptors, reinforces the hypothesis that the presence of matrix and extracellular vesicles are crucial for the development of vascular mineralization in enzootic calcinosis. It is proposed that the two different VSMC-S phenotypes in calcinosis are due to the expression of at least two genetically different types of these cells induced by the action of 1,25(OH)2D3. © The Author(s) 2022. MenosABSTRACT - Vascular mineralization is a hallmark of enzootic calcinosis. Histopathological, ultrastructural, and immunohistochemical investigations were performed on the external carotid arteries of seven sheep naturally poisoned by Nierembergia veitchii. Histologically, moderate to marked hyperplasia of the tunica intima was observed without mineralization. The tunica media exhibited mild to severe mineralization and osteochondroid metaplasia. Sheep with enzootic calcinosis showed arterial overexpression of osteopontin and tissue-nonspecific alkaline phosphatase and immunolabeling for osteonectin and osteocalcin in both intima and media layers of the tested arteries. The main ultrastructural finding in the tunica media was a marked phenotypic change of vascular smooth muscle cells from a contractile phenotype (VSMC-C) into a synthetic phenotype (VSMC-S). In the tunica media, VSMC-S produced matrix and extracellular vesicles, forming mineralizable granules associated with arterial mineralization. VSMC-S were also present in the tunica intima, but matrix and extracellular vesicles and mineralization were not observed. The absence of matrix and extracellular vesicles in the intimal hyperplasia, even in the presence of noncollagenous bone proteins, tissue-nonspecific alkaline phosphatase, and vitamin D receptors, reinforces the hypothesis that the presence of matrix and extracellular vesicles are crucial for the development of vascular mineralization in enzootic calcinosis. It ... Presentar Todo |
Palabras claves : |
Arterial mineralization; Arteries; Enzootic calcinosis; Exosomes; Pathogenesis; PLATAFORMA DE SALUD ANIMAL; Toxicity; Vascular smooth muscle cells. |
Asunto categoría : |
L50 Fisiología y bioquímica animal |
Marc : |
LEADER 03391nam a2200313 a 4500 001 1063233 005 2022-11-30 008 2022 bl uuuu u01u1 u #d 022 $a0300-9858 024 7 $a10.1177/03009858221098430$2DOI 100 1 $aMACHADO, M. 245 $aPoisoning by Nierembergia veitchii$bEffects on vascular smooth muscle cells in the pathogenesis of enzootic calcinosis.$h[electronic resource] 260 $aVeterinary Pathology, 2022, Volume 59, Issue 5, pages 814-823. doi: https://doi.org/10.1177/03009858221098430$c1177 500 $aArticle history: Article first published online May 19, 2022; Published online September 2022. -- Corresponding Author: Franklin Riet-Correa, Postgraduate Program in Animal Science in the Tropics, School of Veterinary Medicine and Animal Science, Federal University of Bahia, Salvador, Bahia 40170-110, Brazil. Email: franklinrietcorrea@gmail.com -- This work was funded by National Institute of Agricultural Research (INIA) of Uruguay (Project CL 44), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil, (Finance Code 001) and National University of La Plata (Project V270). A postgraduate scholarship was provided to Mizael Machado by INIA, Uruguay. 520 $aABSTRACT - Vascular mineralization is a hallmark of enzootic calcinosis. Histopathological, ultrastructural, and immunohistochemical investigations were performed on the external carotid arteries of seven sheep naturally poisoned by Nierembergia veitchii. Histologically, moderate to marked hyperplasia of the tunica intima was observed without mineralization. The tunica media exhibited mild to severe mineralization and osteochondroid metaplasia. Sheep with enzootic calcinosis showed arterial overexpression of osteopontin and tissue-nonspecific alkaline phosphatase and immunolabeling for osteonectin and osteocalcin in both intima and media layers of the tested arteries. The main ultrastructural finding in the tunica media was a marked phenotypic change of vascular smooth muscle cells from a contractile phenotype (VSMC-C) into a synthetic phenotype (VSMC-S). In the tunica media, VSMC-S produced matrix and extracellular vesicles, forming mineralizable granules associated with arterial mineralization. VSMC-S were also present in the tunica intima, but matrix and extracellular vesicles and mineralization were not observed. The absence of matrix and extracellular vesicles in the intimal hyperplasia, even in the presence of noncollagenous bone proteins, tissue-nonspecific alkaline phosphatase, and vitamin D receptors, reinforces the hypothesis that the presence of matrix and extracellular vesicles are crucial for the development of vascular mineralization in enzootic calcinosis. It is proposed that the two different VSMC-S phenotypes in calcinosis are due to the expression of at least two genetically different types of these cells induced by the action of 1,25(OH)2D3. © The Author(s) 2022. 653 $aArterial mineralization 653 $aArteries 653 $aEnzootic calcinosis 653 $aExosomes 653 $aPathogenesis 653 $aPLATAFORMA DE SALUD ANIMAL 653 $aToxicity 653 $aVascular smooth muscle cells 700 1 $aCASTRO, M.B. 700 1 $aWILSON, T. M. 700 1 $aGONÇALVES , A. A. B. 700 1 $aPORTIANSKY, E. 700 1 $aRIET-CORREA, F. 700 1 $aBARROS, S. S.
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